Evidence-Based Framework for Identifying Opioid Use Disorder in Administrative Data: A Systematic Review and Methodological Development Study

This systematic review and methodological development study synthesized existing algorithms for identifying OUD in administrative claims and electronic health record data. The authors cataloged the ICD diagnosis codes, procedure codes, and medication indicators used across published studies to define OUD cases in administrative databases. The review revealed substantial heterogeneity in how OUD is operationalized across the research literature, with varying sensitivity and specificity depending on the codes and criteria employed. Based on the synthesis, the authors developed an evidence-based framework intended to standardize OUD identification for research purposes.